Which medication is predominantly introduced into tissues using phonophoresis?

Phonophoresis is a technique that uses ultrasound waves to enhance the transdermal delivery of various medications into tissues. The medication most commonly associated with phonophoresis is hydrocortisone. Hydrocortisone is a corticosteroid that can effectively reduce inflammation and is often used to treat various musculoskeletal conditions. The ultrasound energy helps to increase the permeability of the skin and facilitate the absorption of hydrocortisone, making it more effective in reaching the underlying tissues where it can exert its therapeutic effects.

In contrast, other medications listed, such as Advil (which contains ibuprofen), cortisone, and ibuprofen itself, are not typically delivered through phonophoresis in clinical practices. These medications either work systemically or are more effectively administered through other routes, like oral ingestion or direct injection, rather than through enhanced transdermal delivery methods like phonophoresis.