Leukotrienes are primarily responsible for what process?

Leukotrienes are lipid mediators that play a significant role in the inflammatory response. Their primary function is to facilitate the margination of leukocytes, which is the process whereby white blood cells move toward the site of injury or infection by adhering to the endothelium of blood vessels. This process is crucial during the early stages of inflammation, as it allows leukocytes to exit the bloodstream and migrate to the tissues where they can help combat pathogens and aid in tissue repair.

By promoting the adhesion of these cells to the blood vessel walls, leukotrienes ensure that an adequate immune response is mounted. This is pivotal in various conditions, particularly during allergic reactions, asthma, and other immune responses. Understanding the role of leukotrienes in this context highlights their importance in orchestrating the inflammatory process and the body's response to injury and infection.